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論文発表 ?2006 ＊ Papers
 2006年

Diastereoselective Horner-Wadsworth-Emmons Reaction for the Synthesis of Tetrasubstituted Alkenes with an Axis of Chirality.
S. Sano, S. Abe, T. Azetsu, M. Nakao, M. Shiro, and Y. Nagao,
Letters in Organic Chemistry, 3 (11), 798-801 (2006).

Lipase-Catalyzed Enantioselective Acetylation of Prochiral N-Cbz-2-Alkyl-2-Amino-1,3-Propanediols and Enantiodivergent Synthesis of α-Benzylserine.
S. Sano, M. Nakao, M. Takeyasu, T. Honjo and Y. Nagao,
Letters in Organic Chemistry, 3 (10), 764-767 (2006).

Tandem Reduction?Olefination of Triethyl 2-Acyl-2-fluoro-2-phosphonoacetates and a Synthetic Approach to Cbz-Gly-Ψ[(Z)-CF=C]-Gly Dipeptide Isostere.
S. Sano, Y. Kuroda, K. Saito, Y. Ose and Y. Nagao,
Tetrahedron, 62 (51), 11881-11890 (2006).

Efficient Synthesis of Isothiocyanates Based on the Tandem Staudinger/aza-Wittig Reactions and Mechanistic Consideration of the Tandem Reactions.
T. Isoda, K. Hayashi, S. Tamai, T. Kumagai, and Y. Nagao,
Chemical & Pharmaceutical Bulletin, 54 (11), 1616-1619 (2006).

Novel Deconjugative Esterification of 2-Cyclohexylideneacetic Acids through 4-(Pyrrolidin-1-yl)pyridine?catalyzed Carbodiimide Couplings.
S. Sano, E. Harada, T. Azetsu, T. Ichikawa, M. Nakao, and Y. Nagao,
Chemistry Letters, 35 (11), 1286-1287 (2006).

Synthesis of Novel Silacyclobutene Derivatives Utilizing Zirconocene- and Titanocene-ethylene Complexes.
C. K. Jin, T. V. Dang, Y. Ikee, T. Yamada, S. Sano, M. Shiro, and Y. Nagao,
Heterocycles, 70 (1), 71-75 (2006).

A Practical and Facile Synthesis of Azetidine Derivatives for Oral Carbapenem, L-084.
T. Isoda, I. Yamamura, S. Tamai, T. Kumagai, Y. Nagao,
Chemical & Pharmaceutical Bulletin, 54 (10), 1408-1411 (2006).

Practical Synthesis of New Chiral cis-Phthalazinones with Potential for High Phosphodiesterase (PDE-4) Inhibitory Activity.
T. V. Dang, C. K. Jin, M. Miyamoto, Y. Ikee, T. Masuda, S. Sano, M. Shiro, and Y. Nagao,
Heterocycles, 68 (10), 2133-2144 (2006).

An Efficient Method for the Synthesis of 3-Mercapto-1-(1,3-thiazolin-2-yl)azetidine Useful for the Pendant Moiety of Oral Carbapenem, L-084.
T. Isoda, S. Tamai, T. Kumagai, and Y. Nagao,
Heterocycles, 68 (9), 1821-1824 (2006).

Fab Fragment Labeled with ICG-derivative for Detecting Digestive Tract Cancer.
H. Yano, N. Muguruma, S. Ito, E. Aoyagi, T. Kimura, Y. Imoto, J. Cao, S. Inoue, S. Sano, Y. Nagao, and H. Kido,
Photodiagnosis and Photodynamic Therapy, 3 (3), 177-183 (2006).

Highly Stereoselective Asymmetric Pummerer Reactions That Incorporate Intermolecular and Intramolecular Nonbonded S●●●O Interactions.
Y. Nagao, S. Miyamoto, M. Miyamoto, H. Takeshige, K. Hayashi, S. Sano, M. Shiro, K. Yamaguchi, and Y. Sei,
Journal of the American Chemical Society, 128 (30), 9722-9729 (2006).

A Novel and Efficient Darzens Reaction Catalyzed by Magnesium Bromide.
S. Sano, M. Miyamoto, T. Mitani, and Y. Nagao,
Heterocycles, 68 (3), 459-463 (2006).

Optimal Labeling Condition of Antibodies Available for Immunofluorescence Endoscopy.
Y. Tadatsu, N. Muguruma, S. Ito, M. Tadatsu, Y. Kusaka, K. Okamoto, Y. Imoto, H. Taue, S. Sano, and Y. Nagao,
The Journal of Medical Investigation, 53 (1/2), 52-60 (2006).

Principle and Clinical Usefulness of the Infrared Fluorescence Endoscopy.
S. Ito, N. Muguruma, T. Kimura, H. Yano, Y. Imoto, K. Okamoto, M. Kaji, S. Sano, and Y. Nagao,
The Journal of Medical Investigation, 53 (1/2), 1-8 (2006).

Expeditious Syntheses of Conjugated Allenyl Esters and Oxazoles through a Cascade Reaction of α-Alkynyl Malonates under Alkaline Conditions.
S. Sano, H. Shimizu, K. Kim, W. S. Lee, M. Shiro, and Y. Nagao,
Chemical & Pharmaceutical Bulletin, 54 (2), 196-203 (2006).

Syntheses and Pharmacokinetic Studies of Prodrug Esters for the Development of Oral Carbapenem, L-084.
T. Isoda, H. Ushirogochi, K. Satoh, T. Takasaki, I. Yamamura, C. Sato, A. Mihira, T. Abe, S. Tamai, S. Yamamoto, T. Kumagai, and Y. Nagao,
Journal of Antibiotics, 59(4), 241-247 (2006).
 2005年

Highly Enantioselective Catalytic Thiolysis of Prochiral Cyclic Dicarboxylic Anhydrides Utilizing a Bifunctional Chiral Sulfonamide.
T. Honjo, S. Sano, M. Shiro, and Y. Nagao,
Angewante Chemie, International Edition, 44 (36), 5838-5841 (2005).

Practical Synthesis of Chiral cis-Cyclohex-4-ene-1,2-dicarboxylic Acid Derivatives by Utilizing (4S)-Isopropyl-1,3-thiazolidine-2-thione.
T. V. Dang, M. Miyamoto, S. Sano, M. Shiro, and Y. Nagao,
Heterocycles, 65 (5), 1139-1157 (2005).

Trimethylaluminum-Induced Diastereoselective Methylation onto Ethyl 2-Oxocyclopentane-1-carboxylate and Isomerization between the Dimethylaluminium-Alkoxide Products.
S. Sano, H. Shimizu, and Y. Nagao,
Tetrahedron Letters, 46 (16), 2887-2891 (2005).

Facile Generation Method for Conjugated Allenyl Esters Based on retro-Dieckmann-Type Ring-Opening Reactions.
S. Sano, H. Shimizu, and Y. Nagao,
Tetrahedron Letters, 46 (16), 2883-2886 (2005).

A Facile Synthesis of Novel Chiral Phosphonoacetates Bearing a Stereogenic Phosphorus Atom.
S. Sano, E. Kujime, Y. Takemoto, M. Shiro, and Y. Nagao,
Chemical & Pharmaceutical Bulletin, 53 (1), 131-134 (2005).

Efficient Synthesis of Functionalized Benzazepine Derivatives Utilizing Intramolecular Mitsunobu Reaction.
T. Ohtani, Y. Kawano, K. Kitano, J. Matsubara, M. Komatsu, M. Uchida, F. Tabusa, and Y. Nagao.
Heterocycles, 66 (1), 481-502 (2005).
 2004年

Intramolecular Nonbonded S●●●O Interaction in Acetazolamide and Thiadiazolinethione Molecules in Their Dimeric Crystalline Structures and Complex Crystalline Structures with Enzymes.
Y. Nagao, T. Honjo, H. Iimori, S. Goto, S. Sano, M. Shiro, K. Yamaguchi, and Y. Sei,
Tetrahedron Letters, 45 (47), 8757-8761 (2004).

New Ring-Expansion Reactions of Hydroxy Propenoyl Cyclic Compounds under the Palladium(0)/Phosphine-Catalyzed Conditions.
Y. Nagao, S. Tanaka, A. Ueki, M. Kumazawa, S. Goto, T. Ooi, S. Sano, and M. Shiro,
Organic Letters, 6 (13), 2133-2136 (2004).

New Synthetic Methods for Seven- and Eight-Membered Cyclic Ethers Based on the Ring-Expansion Reactions of Hydroxy or Lithioxy Methoxyallenylisochroman Derivatives.
Y. Nagao, S. Tanaka, K. Hayashi, S. Sano, and M. Shiro,
Synlett, (3), 481-484 (2004).

Structure-Activity Relationships of Adenosine A3 Receptor Ligands: New Potential Therapy for the Treatment of Glaucoma.
T. Okamura, T. Kurogi, K. Hashimoto, S. Sato, H. Nishikawa, K. Kiryu, and Y. Nagao,
Bioorganic & Medicinal Chemistry Letters, 14 (14), 3775-3779 (2004).

Facile Synthesis of Fused 1,2,4-Triazolo[1,5-c]pyrimidine Derivatives as Human Adenosine A3 Receptor Ligands.
T. Okamura, Y. Kurogi, K. Hashimoto, H. Nishikawa, Y. Nagao,
Bioorganic & Medicinal Chemistry Letters, 14 (10), 2443-2446 (2004).

Mechanistic Considerations for the Consecutive Cyclization of 2,3-Dibromopropylamine Hydrobromide Giving a Strained Molecule, 1-Azabicyclo[1.1.0]butane.
K. Hayashi, Y. Ikee, S. Goto, M. Shiro, Y. Nagao,
Chemical & Pharmaceutical Bulletin, 52 (1), 89-94.
 2003年

Principle and Clinical Usefulness of the Infrared Fluorescence Endoscope.
S. Ito, N. Muguruma, S. Hayashi, Y. Kusaka, M. Tadatsu, Y. Tadatsu, K. Okamoto, Y. Imoto, K. Inayama, T. Bando, S. Taoka, M. Takagawa, K Ii, Y. Nagao, S. Sano, S. Shibamura, K. Ishida, and K. Nakamura,
Biomedical Thermology, 23 (2), 77-97 (2003).

A New Convenient Method for Synthesis of 3-(2-Oxoethylidene)isoindolin-1-ones Employing Palladium(II) Acetate and DDQ.
A. Ueki, S. Tanaka, M. Kumazawa, T. Ooi, S. Sano, and Y. Nagao,
Heterocycles, 61 (1), 449-457 (2003).

(E)-Selective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones with Bis(2,2,2-trifluoroethyl)phosphonoacetic Acid.
S. Sano, Y. Takemoto, and Y. Nagao,
Tetrahedron Letters, 44 (49), 8853-8855 (2003).

Cyclization, Ring Expansion, and Several Cascade Reactions Utilizing Allenylic Molecular Structure Characteristics.
Y. Nagao and S. Sano,
Journal of Synthetic Organic Chemistry, Japan, 61 (11), 1088-1098 (2003).

(E)-Selective Horner-Wadsworth-Emmons Reaction of Aldehydes with bis-(2,2,2-Trifluoroethyl)phosphonoacetic Acid.
S. Sano, Y. Takemoto, and Y. Nagao,
Arkivoc, part (viii), 93-101 (2003).
http://www.arkat-usa.org/get-file/18718/

A New Infrared Fluorescent-Labeling Agent and Labeled Antibody for Diagnosing Microcancers.
M. Tadatsu, S. Ito, N. Muguruma, Y. Kusaka, K. Inayama, T. Bando, Y. Tadatsu, K. Okamoto, K. Ii, Y. Nagao, S. Sano, and H. Taue,
Bioorganic & Medicinal Chemistry, 11 (15), 3289-3294 (2003).

Tandem Reduction-Olefination for the Stereoselective Synthesis of (Z)-α-Fluoro-α,β-unsaturated Esters.
S. Sano, K. Saito, and Y. Nagao,
Tetrahedron Letters, 44 (20), 3987-3990 (2003).

Asymmetric Horner-Wadsworth-Emmons Reaction Utilizing Isomannide and Isosorbide Derivatives as Chiral Auxiliaries.
S. Sano, R. Teranishi, F. Nakano, K. In, H. Takeshige, T. Ishii, M. Shiro, and Y. Nagao,
Heterocycles, 59 (2), 793-804 (2003).

Preface.
Y. Nagao,
Journal of Synthetic Organic Chemistry, Japan, 61 (3), 191 (2003).
 2002年

Toward (Z)-Selective Horner-Wadsworth-Emmons Reaction of Aldehydes with 2-Fluoro-2-diethylphosphonoacetic Acid.
S. Sano, R. Teranishi, and Y. Nagao,
Tetrahedron Letters, 43 (50), 9183-9186 (2002).

Stereoselective Synthesis of Tetrasubstituted (Z)-Alkenes form Aryl Alkyl Ketones Utilizing the Horner-Wadsworth-Emmons Reaction.
S. Sano, T. Takehisa, S. Ogawa, K. Yokoyama, and Y. Nagao,
Chemical & Pharmaceutical Bulletin, 50 (9), 1300-1302 (2002).

A Facile Method for the Stereoselective Horner-Wadsworth-Emmons Reaction of Aryl Alkyl Ketones.
S. Sano, K. Yokoyama, M. Shiro, and Y. Nagao,
Chemical & Pharmaceutical Bulletin, 50 (5), 706-709 (2002).

Synthesis of New Chiral Sulfinyldiacetic Acid Derivatives and Attempt at Chemoselective Asymmetric Pummerer Reaction.
Y. Nagao, S. Miyamoto, K. Hayashi, A. Mihira, and S. Sano,
Chemical & Pharmaceutical Bulletin, 50 (4), 558-562 (2002).

Remarkable Discrepancy in the Predominant Structures of Acyl(or Thioacyl)aminothiadiazoles, Acyl(or Thioazyl)aminooxadiazoles and Related Compounds Having the Potential for Rotational, Geometrical and Tautomeric Isomerism.
Y. Nagao, H. Iimori, S. Goto, T. Hirata, S. Sano, H. Chuman, and M. Shiro,
Tetrahedron Letters, 43 (9), 1709-1712 (2002).

Highly Chemoselective Pummerer Reactions of Sulfinyldiacetic Acid Derivative.
Y. Nagao, S. Miyamoto, K. Hayashi, A. Mihira, and S. Sano,
Tetrahedron Letters, 43 (8), 1519-1522 (2002).

Palladium(0)-Catalyzed Ring Expansion Reactions of Hydroxy Methoxyallenylisoindolinones via Inter- and Intramolecular Carbopalladation Using Aryl and Vinyl Halides.
Y. Nagao, S. Tanaka, A. Ueki, I.-Y. Jeong, S. Sano, and M. Shiro,
Synlett, (3), 480-482 (2002).

Facile Palladium(0)-Catalyzed Ring Expansion Reactions of Hydroxy Methoxyallenyl Cyclic Compounds via Hydropalladation.
Y. Nagao, A. Ueki, K. Asano, S. Tanaka, S. Sano, and M. Shiro,
Organic Letters, 4 (3), 455-457 (2002).

Enantioselective Horner-Wadsworth-Emmons Reaction for the Asymmetric Synthesis of α-Fluoro-α,β-unsaturated Esters.
S. Sano, K. Yokoyama, R. Teranishi, M. Shiro, and Y. Nagao,
Tetrahedron Letters, 43 (2), 281-284 (2002).

1,2,4-Triazolo[5,1-i]purine Derivatives as Highly Potent and Selective Human Adenosine A3 Receptor Ligands.
T. Okamura, Y. Kurogi, H. Nishikawa, K. Hashimoto, H. Fujiwara, Y. Nagao,
Journal of Medicinal Chemistry, 45 (17), 3703-3708 (2002).

Synthesis of Azetidine Derivatives Using 1-Azabicyclo[1.1.0]butane.
K. Hayashi, S. Hiki, T. Kumagai, Y. Nagao,
Heterocycles, 56 (1/2), 433-442 (2002).

Development of New Reactions and Their Pharmaceutical Application Based on the Molecular Structure Characteristics.
Y. Nagao,
Yakugaku Zasshi, 122 (1), 1-27 (2002).


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